Natasha Lyonne

as Vivian Abromowitz

Alan Arkin

as Murray Samuel Abromowitz

Marisa Tomei

as Rita Abromowitz

Eli Marienthal

as Rickey Abromowitz

David Krumholtz

as Ben Abromowitz

Kevin Corrigan

as Eliot Arenson

Jessica Walter

as Doris

Mena Suvari

as Rachel Hoffman

Carl Reiner

as Mickey

Harris Laskawy

as Charlie the Cook

Rita Moreno

as Belle Abromowitz

Bryna Weiss

as Saleslady

Charlotte Stewart

as Landlady

Marley McClean

as Brooke

Mary Portser

as Mrs. Hoffman

Jay Patterson

as Dr. Grossman

Natalie Karp

as Nurse Curtrell

Jock MacDonald

as Man at Brymans

Rich Willis

as EMS Guy #1

Armand Reiser

as EMS Guy #2

Jack Tracy

as Cop #1

Sally Schaub

as Waitress

Scotty Atkins

as Waiter (uncredited)

Mykal Wayne Williams

as Waiter (uncredited)