Ryan Reynolds

as Wade Wilson / Deadpool

Morena Baccarin

as Vanessa

Ed Skrein

as Ajax

T.J. Miller

as Weasel

Gina Carano

as Angel Dust

Leslie Uggams

as Blind Al

Brianna Hildebrand

as Negasonic Teenage Warhead

Stefan Kapičić

as Colossus (voice)

Karan Soni

as Dopinder

Randal Reeder

as Buck

Michael Benyaer

as Warlord

Style Dayne

as Jeremy (Pizza Guy)

Kyle Cassie

as Gavin Merchant

Taylor Hickson

as Meghan Orlovsky

Ayzee

as Teen Girl #1

Naika Toussaint

as Teen Girl #2

Isaac C. Singleton, Jr.

as Boothe

Justyn Shippelt

as Arcade Ticket Taker

Donna Yamamoto

as Oncologist

Jed Rees

as Recruiter

Hugh Scott

as David Cunningham

Cindy Piper

as Chinatown Merchant

Em Haine

as Whisper Girlfriend

Aatash Amir

as Whisper Boyfriend

Chad Riley

as Pool Hall Goon

Paul Belsito

as Fight Club Boss

Darcey Johnson

as Garbage Truck Driver

Kyle Rideout

as Super Soldier #1

Jason William Day

as Super Soldier #2

Stan Lee

as Strip Club DJ

Benjamin Wilkinson

as No5 Orange Manager

Rachel Sheen

as Strip Club Worker

Paul Lazenby

as Flight Deck Guard

Rob Hayter

as Bob

Andre Tricoteux

as On-Set Colossus (uncredited)

Victoria De Mare

as Stripper (uncredited)

Heather Ashley Chase

as Stripclub Pole Performer (uncredited)

Kayla Adams

as Waitress Kelly (uncredited)

Olesia Shewchuk

as Guadalajaran Mother (uncredited)

Fabiola Colmenero

as Guadalajaran Nurse (uncredited)

Matthew Hoglie

as Strip Club Patron (uncredited)

Colleen Bradford

as Bar Patron (uncredited)

John Dryden

as Thug #2 (uncredited)

David Hardware

as Strip Club Spectator (uncredited)

Tony Chris Kazoleas

as Fight Club Spectator (uncredited)

Rob Liefeld

as Liefeld (uncredited)

David Longworth

as Elderly Man (uncredited)

Michael Neumeyer

as Soldier #1 (uncredited)

Sean Quan

as Ten-year-old Boy (uncredited)

Anthony J. Sacco

as Thug #3 (uncredited)

David Santana

as Biker in Strip Club (uncredited)

Bronwyne Sloley

as Fight Club Spectator (uncredited)

Dan Zachary

as Biker (uncredited)