Sidney Toler

as Charlie Chan

Victor Sen Yung

as Jimmy Chan

Cesar Romero

as Fred Rhadini

Douglas Fowley

as Peter Lewis

Pauline Moore

as Eve Cairo

Donald MacBride

as Deputy Police Chief J.J. Kilvaine

Douglass Dumbrille

as Stewart Salsbury, alias Thomas Gregory

Trevor Bardette

as Dr. Zodiac's Servant

Gerald Mohr

as Dr. Zodiac (in disguise)

Wally Vernon

as Elmer

June Gale

as Myra Rhadini

Billie Seward

as Mrs. Bessie Sibley

Sally Blane

as Stella Essex

Charles Halton

as Uncle Redley

Louis Jean Heydt

as Paul Essex

Jack Chefe

as Audience Member

Heinie Conklin

as First Taxicab Driver

Sayre Dearing

as Audience Member

Bud Geary

as Cop at Station House

Harold Goodwin

as Airplane Steward

Edith Hallor

as Toots - Stout Woman

Fred Kelsey

as Detective - in Cab and at Theatre

Al Kikume

as Waiter at Hawaiian Village

Kay Linaker

as Egyptian Princess Ectoplasm

Hank Mann

as Second Taxicab Driver

Margaret Mann

as Airplane Passenger

Frank Meredith

as Second Detective

Harold Miller

as Audience Member

Bruce Mitchell

as Police Desk Sergeant

Hans Moebus

as Audience Member

Bert Moorhouse

as Audience Member

David Newell

as Audience Member

Imboden Parrish

as Plane Passenger

Tom Quinn

as Man at Landing Gate

Arthur Rankin

as Airways Official

Fred Rapport

as Audience Member

Gloria Roy

as Plane Passenger

Jeffrey Sayre

as Man at Landing Gate

Harry Strang

as Taxicab Dispatcher

Charles Tannen

as Plane Passenger

Edwin Tuttle

as Audience Member

John Elliott

as Doctor - Backstage