Tom Cruise

as Barry Seal

Domhnall Gleeson

as Monty 'Schafer'

Sarah Wright

as Lucy Seal

Jesse Plemons

as Sheriff Downing

Caleb Landry Jones

as JB

Lola Kirke

as Judy Downing

Jayma Mays

as Dana Sibota

Alejandro Edda

as Jorge Ochoa

Benito Martinez

as James Rangel

E. Roger Mitchell

as Agent Craig McCall

Jed Rees

as Louis Finkle

Fredy Yate

as Carlos Lehder

Mauricio Mejía

as Pablo Escobar

Robert Farrior

as Oliver North

Morgan Hinkleman

as Christina

Alberto Ospino

as Manuel Noriega

Felipe Bernedette

as Translator

Daniel Lugo

as Adolfo Calero

Jayson Warner Smith

as Bill Cooper (Snowbird #1)

William Mark McCullough

as Pete (Snowbird #2)

April Billingsley

as Stewardess

Lauren Boyd

as Secretary

Lauren Revard

as Teller

Marcus Hester

as Parka

Mike Pniewski

as Willie (State Police)

Frank Licari

as DEA Agent #1

Alex Collins

as ATF #1

Scott Poythress

as ATF #2

Connor Trinneer

as George W. Bush / Texan

Alpha Trivette

as Judge Linkletter

Kevin L. Johnson

as Agent Horace Wainwright

DeVere Jehl

as Plains Clothed Man

Emilio Sierra

as Héctor (Colombian Driver)

Leon Lamar

as Elderly Man

Tony Guerrero

as Federico Vaughan

Maria Howell

as NSC Woman

Darla Delgado

as Customs Agent

Justice Leak

as DEA Agent Winter

Robert Pralgo

as Gary (Cubicle Mate)

Mickey Sumner

as North's Aide Fawn Hall

Daniel Thomas May

as CIA Man

Chloe Swan Sparwath

as LeAnn

Alex Quarles

as Aaron

Trip McCarthy

as Dean

Zachary Powell

as Dean

Daniel Diaz

as Sandinista Soldier

Byron Wigfall

as Contra #1

Matt Mercurio

as FBI Analyst

Carlos Lopez Jr.

as CIA Station Chief

Jairo Ordóñez

as Scar

Jeff Olsen

as State Trooper

Stephen Conroy

as Military Police / Advisor

Juan Esteban Ramírez Toro

as Antonio (Bull Fighter)

Lara Grice

as Female Reporter (uncredited)

Sharon Conley

as DEA Agent Grace (uncredited)

Chris Gann

as Donor #2 (uncredited)

Johnny Otto

as Pilot (uncredited)

Kayla Perkins

as Waitress (uncredited)

Michael Mercaldi

as Sandinista (uncredited)

Dan Southworth

as Agent Winters (uncredited)

Bill Billions

as Radar Op. #1 (uncredited)

Ronald Reagan

as Self (archive footage) (uncredited)

Muhammad Ali

as Self (archive footage) (uncredited)

Nancy Reagan

as Self (archive footage) (uncredited)