Wesley Snipes

as Blade

Stephen Dorff

as Deacon Frost

Kris Kristofferson

as Whistler

N'Bushe Wright

as Karen

Donal Logue

as Quinn

Udo Kier

as Dragonetti

Arly Jover

as Mercury

Traci Lords

as Racquel

Kevin Patrick Walls

as Krieger

Tim Guinee

as Curtis Webb

Sanaa Lathan

as Vanessa

Eric Edwards

as Pearl

Donna Wong

as Nurse

Carmen Thomas

as Senior Resident

Shannon Lee

as Resident

Kenny Johnson

as Heatseeking Dennis

Clint Curtis

as Creepy Morgue Guy

Judson Scott

as Pallantine

Sidney S. Liufau

as Japanese Doorman

Keith Leon Williams

as Kam

Andray Johnson

as Paramedic

Stephen R. Peluso

as Paramedic

Marcus Aurelius

as Pragmatic Policeman

John Enos III

as Blood Club Bouncer

Eboni 'Chrystal' Adams

as Martial Arts Kid

Lyle Conway

as Reichardt

Freeman White

as Menacing Stud

D.V. DeVincentis

as Vampire Underling

Marcus Salgado

as Frost's Goon

Esau McKnight

as Frost's Goon

Erl Van Douglas

as Von Esper

Matt Schulze

as Crease

Lennox Brown

as Pleading Goon

Yvette Ocampo

as Party Girl

Irena Stepić

as Slavic Vampire Lord

Jenya Lano

as Russian Woman

Levan Uchaneishvili

as Russian Vampire

Chris Casamassa

as Vampire (uncredited)

Ron Cobert

as Vampire (uncredited)

Laura Cordova

as Vampire (uncredited)

Nikki DiSanto

as Vampire Victim (uncredited)

Ryan Glorioso

as Blood Bath Vampire (uncredited)

Al Goto

as Henchman (uncredited)

Mark Heenehan

as Club Patron (uncredited)

Steven Ho

as Frost's Goon (uncredited)

Jeff Imada

as Henchman (uncredited)

Diana Lee Inosanto

as Blood Bath Vampire (uncredited)

Steven D. Ito

as Henchman (uncredited)

Elliott James

as Blood Club (uncredited)

Ted King

as Vampire at Rave (uncredited)

Henry Kingi

as Bartender (uncredited)

Will Leong

as Henchman (uncredited)

David Matthiessen

as Vampire (uncredited)

Stephen Norrington

as Vampire (uncredited)

Gerald Okamura

as Vampire (uncredited)

Frankie Ray

as Vampire Lord (uncredited)

Simon Rhee

as Henchman (uncredited)

Michael Stumpf

as Sword Thrower (uncredited)

Jen Taylor

as Vampire (uncredited)