Jessica Chastain

as Amy Loughren

Eddie Redmayne

as Charles Cullen

Nnamdi Asomugha

as Danny Baldwin

Kim Dickens

as Linda Garran

Malik Yoba

as Sam Johnson

Alix West Lefler

as Alex Loughren

Noah Emmerich

as Tim Braun

Gabe Fazio

as Tom Anderson

Ajay Naidu

as Dr. Robert Hind

Moe Irvin

as Mark Rossi

Maria Dizzia

as Lori Lucas

Shaun O'Hagan

as Prosecutor Ellis

Marcia Jean Kurtz

as Jackie

Myra Lucretia Taylor

as Vivian Neal

Denise Pillott

as Nurse 1

Dartel McRae

as Nurse 2

Joseph Fugelo

as Dr. Collins

Judith Delgado

as Ana Martinez

Jesus-Papoleto Melendez

as Sam Martinez

Devyn McDowell

as Maya Loughren

Jennean Farmer

as Receptionist

Navya La Shay

as Hospital Admin

David Lavine

as Duncan Beattie

Bruce MacVittie

as Malcolm Burrel

Brooke Stacy Mills

as Nurse Hardwick

Charlotte Cohn-Williams

as Dr. Moore

Christine Healy

as Assistant

Maria Farrow

as Dr. Peters

Alex Bartner

as Messenger

Anjelica Bosboom

as Kelly Anderson

Rebecca Watson

as Nurse Sandra

Jennifer Regan

as ER Nurse

Beth Dixon

as Diner Waitress

Brian Sayers

as State Trooper

Steve Antonucci

as Grave Digger (uncredited)

Evan Bass

as Nurse Geddes (uncredited)

Andrew James Bleidner

as Alex Lombardo (uncredited)

David Boston

as Driver (uncredited)

Chris Henry Coffey

as Dr. Steven Reed (uncredited)

Victor Cruz

as Gene Smith (uncredited)

Sheetal Deo

as Doctor Day Player (uncredited)

Marcia M Francis

as Patient (uncredited)

Gina Jun

as Doctor (uncredited)

Becca Marks

as Night Nurse (uncredited)

Lauren Yaffe

as ICU Patient (uncredited)