Anthony Ramos

as Noah Diaz

Dominique Fishback

as Elena Wallace

Peter Cullen

as Optimus Prime (voice)

Ron Perlman

as Optimus Primal (voice)

Peter Dinklage

as Scourge (voice)

Michelle Yeoh

as Airazor (voice)

Pete Davidson

as Mirage (voice)

Liza Koshy

as Arcee (voice)

Cristo Fernández

as Wheeljack (voice)

Luna Lauren Velez

as Breanna Diaz

Dean Scott Vazquez

as Kris Diaz

Tobe Nwigwe

as Reek

Sarah Stiles

as Jillian

Leni Parker

as Ms. Greene

Frank Marrs

as Receptionist

Aidan Devine

as Bishop

Kerwin Jackson

as Hotel Security Guard

Mike Chute

as NYC Police Officer

Tyler Hall

as NYC Police Officer

Sean Tucker

as Bridge Security Guard

Jay Farrar

as Museum Guard

Lucas Huarancca

as Amaru

Amiel Cayo

as Amaru's Son

Santusa Cutipa

as Amaru's Wife

Yesenia Inquillay

as Amaru's Granddaughter

Sumac T'Ika

as Amaru's Granddaughter

Josue Sallo

as Amaru's Grandson

Mellissa Alvarez

as Amaru's Daughter-In-Law

Gloria Cusi

as Amaru's Relative

Michael Kelly

as Agent Burke

Jason D. Avalos

as Security Guard

Lesley Stahl

as Lesley Stahl

John DiMaggio

as Transit / Stratosphere (voice)

David Sobolov

as Rhinox / Battletrap / Apelinq (voice)

Michaela Jaé Rodriguez

as Nightbird (voice)

Colman Domingo

as Unicron (voice)

Tongayi Chirisa

as Cheetor (voice)

Luke Jones

as Additional Voice (voice)

Domenic Di Rosa

as Bus Driver

Seth Fuentes

as Pedestrian

Jimmy Caspeur Leblanc

as Buisnessman