Riccardo Scamarcio

as Caravaggio

Louis Garrel

as The Shadow

Isabelle Huppert

as Costanza Sforza Colonna

Vinicio Marchioni

as Giovanni Baglione

Lolita Chammah

as Anna Bianchini

Micaela Ramazzotti

as Lena Antonietti

Alessandro Haber

as Battista

Michele Placido

as Cardinal Del Monte

Brenno Placido

as Ranuccio

Moni Ovadia

as Filippo Neri

Lorenzo Lavia

as Orazio Gentileschi

Tedua

as Cecco

Maurizio Donadoni

as Papa Paolo V

Gianfranco Gallo

as Giordano Bruno

Gianluca Gobbi

as Scipione Borghese

Duccio Camerini

as Costantino Spada

Carlo Giuseppe Gabardini

as Onorio Longhi

Sebastiano Lo Monaco

as Alof di Wignacourt

Guia Jelo

as Serva di Caravaggio

Michelangelo Placido

as Fratello di Ranuccio

Alberto Onofrietti

as Cugino di Ranuccio

Pietro Micci

as Inquisitore

Davide Paganini

as Cavalier d'Arpino

Lea Gavino

as Artemisia Gentileschi

Tommaso De Bacco

as Fabrizio Colonna

Orfeo Orlando

as Sottoposto Cardillo

Sandro Presta

as Guerico

Gerardo D'Angelo

as Butterato

Leo Mantovani

as Frate Girolamo

Federico Fiorio

as Pedro Montoya

Ciro Cascina

as Mammeta

Marco Mancassola

as Macellaio

Prince Chidozie Manujibeya

as Otello

Silvia Siravo

as Desdemona

Terenzio Del Gaudio

as Sgherro

Alessandro Luzzi

as Paolino

Luigi Chiocca

as Carcerato