Andie MacDowell

as Ann Finnigan

Bruce Davison

as Howard Finnigan

Jack Lemmon

as Paul Finnigan

Tim Robbins

as Gene Shepard

Julianne Moore

as Marian Wyman

Tom Waits

as Earl Piggot

Lily Tomlin

as Doreen Piggot

Fred Ward

as Stuart Kane

Chris Penn

as Jerry Kaiser

Frances McDormand

as Betty Weathers

Madeleine Stowe

as Sherri Shepard

Jennifer Jason Leigh

as Lois Kaiser

Anne Archer

as Claire Kane

Matthew Modine

as Dr. Ralph Wyman

Lili Taylor

as Honey Bush

Robert Downey Jr.

as Bill Bush

Peter Gallagher

as Stormy Weathers

Zane Cassidy

as Casey Finnigan

Joseph C. Hopkins

as Joe Kaiser

Josette Maccario

as Josette Kaiser

Austin Friel

as Austin Shepard

Dustin Friel

as Will Shepard

Cassie Friel

as Sandy Shepard

Jarrett Lennon

as Chad Weathers

Buck Henry

as Gordon Johnson

Huey Lewis

as Vern Miller

Dirk Blocker

as Diner Customer

Alex Trebek

as Alex Trebek

Jerry Dunphy

as Jerry Dunphy

Lyle Lovett

as Andy Bitkower

Lori Singer

as Zoe Trainer / Cello - The Trout Quintet

Danny Darst

as Aubrey Bell

Annie Ross

as Tess Trainer

Robert DoQui

as Knute Willis

Margery Bond

as Dora Willis (as Margerie Bond)

Darnell Williams

as Joe Robbins

Michael Beach

as Jim Stone

Andi Chapman

as Harriet Stone

Deborah Falconer

as Barbara

Susie Cusack

as Nancy

Charles Rocket

as Wally Littleton

Jane Alden

as Mrs. Schwartzmeier

Christian Altman

as Jimmy Miller

William H.D. Marlett

as Jimmy's Friend

Suzanne Calvert

as Tarmac Secretary

Natalie Strong

as Mourner

Jay Della

as Bartender

Jeri Gray

as Club Owner (as Jeruth Persson)

Derek Webster

as Joe Robbins' Pal

Nathaniel Harris

as Joe Robbins' Pal (as Nathaniel H. Harris III)

Ron McPherson

as Makeup Artist

Paul Parkey Jr.

as Diner Patron