Steve Martin

as Stu Preissler

Jack Black

as Brad Harris

Owen Wilson

as Kenny Bostick

Brian Dennehy

as Raymond Harris

Anjelica Huston

as Annie Auklet

Rashida Jones

as Ellie

Rosamund Pike

as Jessica

Dianne Wiest

as Brenda Harris

JoBeth Williams

as Edith

Anthony Anderson

as Bill Clemont

Corbin Bernsen

as Gil Gordon

Barry Shabaka Henley

as Dr. Neil Kramer

Joel McHale

as Barry Loomis

Tim Blake Nelson

as Fuchs

Jim Parsons

as Crane

Kevin Pollak

as Jim Gittelson

Nate Torrence

as Ted Simkin

Steven Weber

as Rick

Zahf Paroo

as Prasad

John Cleese

as Historical Montage Narrator (voice)

Paul Campbell

as Tony

Cindy Busby

as Susie

Greg Kean

as Computer Birder

Eva Bourne

as Birder's Daughter

Bill Dow

as Dr. Paul Elkin

June Squibb

as Old Lady

Craig Bockhorn

as Lawyer

Joey Aresco

as Frank Falucci

Ryan Caltagirone

as Frank Jr.

Al Roker

as New York Weatherman

Christopher Mann

as Security Guard

Jan Bos

as Local Newsman (High Island)

Kate Gajdosik

as Local Newswoman (High Island)

William Samples

as British Tourist

Scott Patey

as Birder (High Island)

Marci T. House

as Troop Leader

Michael Bean

as Waiter

Christopher Redman

as Scott

Devon Weigel

as Karen

Andrew Wilson

as Mike Shin

Gabrielle Rose

as Mary Swit

Calum Worthy

as Colin Debs

Doreen Ramus

as CB Announcer

Terence Kelly

as Pete Shackelford

Steve Darling

as Anchorage Weatherman

Jon Frankel

as Anchorage Anchorman

David James Lewis

as Lanky Birder

Jesse Moss

as Darren

Kath Dugray

as Motel Manager

Morgan Brayton

as Ferry Ticket Seller

Sheelah Megill

as Nurse

Veena Sood

as Nurse Katie

Dee Jay Jackson

as Parking Attendant

Calvin Lee

as Chinese Waiter

Tshering Garie

as Chinese Waitress

Michael Karl Richards

as Vicki's Fiancée (uncredited)

Stacey Scowley

as Vicki (uncredited)