Willem Dafoe

as Cisco

Shanyn Leigh

as Skye

Toni Redman

as Man on phone (voice)

Pat Kiernan

as News Anchor

Francis Kuipers

as Teddy

Selena Mars

as Skype Dancer

Justin Restivo

as Suicide

Bojana Vasik

as Woman with coat

Trung Nguyen

as Delivery Boy

Triana Jackson

as Cisco's Daughter

Dierdra McDowell

as Cisco's Ex

Natasha Lyonne

as Tina

Anita Pallenberg

as Sky's Mother

Paul Hipp

as Noah

José Solano

as Drug Dealer

Judith Salazar

as Friend of Dealer

Paz de la Huerta

as Woman on Street

Frank Aquilino

as Man Outside Bar

Maria Grazia Schirripa

as Wailing Woman

Muriel Sprissler Dafoe

as Cisco's Mother

Nicholas Deceolia

as Man in Window

Tenzin Gyatso

as Self (archive footage) (uncredited)

Al Gore

as Self (archive footage) (uncredited)

Anthony Perullo

as Contrition (uncredited)

Charlie Rose

as Self (archive footage) (uncredited)

Tyler Stone

as Man in Heels (uncredited)

Thomas Michael Sullivan

as Priest (uncredited)

Nicola Tranquillino

as Newscaster (uncredited)